Pig Distal Colonic Mucosa
نویسنده
چکیده
serosal n-butyric acid (O, O,1, 1, or 1O mmollL, adjusted to neutral pH) on the epithelial cell proliferation rate of pig colonic mucosa in organ culture taking crypt cell production rate (CCPR) as the measure of proliferative activity With O or O.1 mmolfL n-butyric acid on the serosal side, luminal n-butyric acid increased CCPR at 1,O mmol/L, and decreased CCPR at 1O mmollL when compared to the Iuminal O mmolfL control, With 1.0 or 1O mmolfL serosal n-butyric acid, luminal n-butyric acid depressed CCPR dose-dependently The above results indicated that n-butyric acid stimulated colonic epithelial cell proliferation at low concentration and inhibit it at high concentration with interaction effect to enhance the inhibitory action. The stimulatory effect of a low dose of serosal n-butyric acid may be
منابع مشابه
K+ channel KVLQT1 located in the basolateral membrane of distal colonic epithelium is not essential for activating Cl- secretion.
The cellular mechanism for Cl(-) and K(+) secretion in the colonic epithelium requires K(+) channels in the basolateral and apical membranes. Colonic mucosa from guinea pig and rat were fixed, sectioned, and then probed with antibodies to the K(+) channel proteins K(V)LQT1 (Kcnq1) and minK-related peptide 2 (MiRP2, Kcne3). Immunofluorescence labeling for Kcnq1 was most prominent in the lateral ...
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